Lens epithelium and radiation cataract. III. The influence of age on the nuclear fragmentation of the meridional row cells following x irradiation

Journal Article · Thu Jul 01 00:00:00 EDT 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575825· OSTI ID:6707885

Worgul, B V; Low, S; Merriam, Jr, G R

Studies were conducted on the effect of age on the production of fragmented nuclei in meridional row (MR) cells following ocular exposure to x radiation. It was found that vulnerability to such damage is maximal approximately 4 weeks postpartum in rats, and that increasingly larger doses of x rays were required to produce equal responses in older animals. Studies on other animals (mice, rabbits, frogs) thought to be resistant to this injury indicate that the failure to see this pathological change in those species is related to age. Although its role in cataractogenesis is unclear, direct damage to the nuclei of MR cells may be ubiquitous among animals susceptible to radiation cataract development.

• Research Organization: Columbia Univ., New York
• OSTI ID: 6707885
• Journal Information: Radiat. Res.; (United States), Vol. 91:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CATARACTS
RADIOINDUCTION
CELL NUCLEI
BIOLOGICAL RADIATION EFFECTS
AGE DEPENDENCE
COMPARATIVE EVALUATIONS
CRYSTALLINE LENS
DOSE-RESPONSE RELATIONSHIPS
EPITHELIUM
LABORATORY ANIMALS
OPHTHALMOLOGY
PATHOLOGY
RADIATION DOSES
RATS
X RADIATION
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CELL CONSTITUENTS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
IONIZING RADIATIONS
MAMMALS
MEDICINE
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SENSE ORGANS
SENSE ORGANS DISEASES
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals