Future of bone marrow transplantation in oncology
The editorial presents an assessment of the current status of bone marrow transportation (BMT) for treatment of leukemia and the problems that must be resolved to render the approach more widely applicable. Studies are in progress which may show that the patient's autologous bone marrow, cryopreserved when it has no detectable tumor and reinfused after supralethal chemoradiotherapy, is associated with long-term, tumor-free survival. Effective chemoradiotherapy regimens may be identified from studies of twin BMT and the potential problem of tumor contamination of infused autologous marrow resolved by using monoclonal antibodies directed to tumor cells. Solving the problems associated with syngeneic, allogenic or autologous BMT may make it possible to use BMT for patients with nonhematologic malignancies sensitive to high doses of chemoradiotherapy. (JMT)
- Research Organization:
- Univ. of Washington and the Fred Hutchinson Cancer Research Center, Seattle, OR
- OSTI ID:
- 6707633
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE MARROW
TRANSPLANTS
LEUKEMIA
RADIOTHERAPY
MONOCLONAL ANTIBODIES
USES
CHEMOTHERAPY
SUPRALETHAL IRRADIATION
WHOLE-BODY IRRADIATION
ANIMAL TISSUES
ANTIBODIES
BODY
DISEASES
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
THERAPY
TISSUES
550603* - Medicine- External Radiation in Therapy- (1980-)