Cerebral perfusion imaging in Alzheimer's disease. Use of single photon emission computed tomography and iofetamine hydrochloride I 123

Journal Article · Sun Feb 01 00:00:00 EST 1987 · Arch. Neurol.; (United States)

DOI:https://doi.org/10.1001/archneur.1987.00520140035014· OSTI ID:6702643

Johnson, K A; Mueller, S T; Walshe, T M; English, R J; Holman, B L

We used single photon emission computed tomography (SPECT) to study 15 patients with Alzheimer's disease and nine controls. Iofetamine hydrochloride I 123 uptake data were recorded from the entire brain using a rotating gamma camera. Activity ratios were measured for the frontal, posterior parietal, posterior, medial, and lateral cortical temporal regions and striate cortex and were normalized by the activity in the cerebellum. Abnormalities in iofetamine hydrochloride I 123 activity were similar to the abnormalities in glucose metabolism observed with positron emission tomography. Cortical tracer activity was globally depressed in patients with Alzheimer's disease, with the greatest reduction in the posterior parietal cortex.

• Research Organization: Brigham and Women's Hospital, Boston, MA
• OSTI ID: 6702643
• Journal Information: Arch. Neurol.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
AMPHETAMINES
ELDERLY PEOPLE
IODINE 123
MENTAL DISORDERS
PERFUSED ORGANS
AGE GROUPS
AGED ADULTS
ANALEPTICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
HUMAN POPULATIONS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MINORITY GROUPS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
POPULATIONS
RADIOISOTOPES
SYMPATHOMIMETICS
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics