Subchronic inhalation toxicity of 1,3,5-trichlorobenzene

Technical Report · Mon Oct 11 00:00:00 EDT 1982

OSTI ID:6702505

Sasmore, D P; Mitoma, C; Tyson, C A; Johnson, J S

Male and female rats were exposed to 0, 10, 100 or 1000 ppM of 1,3,5-trichlorobenzene vapors for 6 hours daily, 5 days a week, for up to 13 weeks. After 4 and 13 weeks of exposure, animals were sacrificed and examined for changes in blood, clinical chemistry, internal organs, and tissues resulting from the 1,3,5-trichlorobenzene treatment. No treatment-related effects on the blood and clinical chemistry were evident. The only effects that were considered treatment-related were a squamous metaplasia and hyperplasia in the respiratory epithelium in the nasal passages of high-dose rats and the increased incidence of dried red material on the faces of these rats during exposures compared with other groups.

• Research Organization: SRI International, Menlo Park, CA (USA)
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 6702505
• Report Number(s): UCRL-15505; ON: DE83002250
• Country of Publication: United States
• Language: English

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