Methylene chloride intoxication in a furniture refinisher. A comparison of exposure estimates utilizing workplace air sampling and blood carboxyhemoglobin measurements
- Univ. of California, San Francisco General Hospital (USA)
A 35-year-old furniture refinisher came to the occupational medicine clinic with complaints of upper respiratory irritation, fatigue, and lightheadedness occurring on a daily basis after using a methylene chloride-containing paint stripper. Determinations of blood carboxyhemoglobin (COHb) on three occasions showed an apparently linear elevation of COHb as a function of hours worked on the day of sampling. COHb levels predicted from spot industrial hygiene measurements were in close concordance with those observed in the patient, indicating the potential usefulness of COHb monitoring in estimating airborne exposure levels. Methylene chloride (or dichloromethane) is an organic solvent that has found wide use as a degreaser, paint remover, aerosol propellant, and a blowing agent for polyurethane foams, and as a solvent in food processing, photographic film production, and plastics manufacturing. Discovery of its unusual metabolic fate--conversion to carbon monoxide in vivo--has earned the compound a special place in the solvent toxicology literature. Demonstration of oncogenicity in experimental animals has occasioned a reconsideration of exposure limits, with emphasis upon stricter controls. In some workplaces, conditions prevail in which controls are inadequate to prevent even acute toxicity, much less long-term exposure risks.
- OSTI ID:
- 6701832
- Journal Information:
- JOM, Journal of Occupational Medicine; (USA), Vol. 32:5; ISSN 0096-1736
- Country of Publication:
- United States
- Language:
- English
Similar Records
In-depth survey report: Assisting furniture strippers in reducing the risk from methylene chloride stripping formulations at Los Angeles Stripping and Refinishing Center, Los Angeles, California
In-depth survey report: The control of methylene chloride in furniture stripping at Kwick Kleen Industrial Solvents, Inc. , Vincennes, Indiana
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARBOXYHEMOGLOBIN
BIOSYNTHESIS
METHYLENE CHLORIDE
TOXICITY
COMPARATIVE EVALUATIONS
ECOLOGICAL CONCENTRATION
INDOOR AIR POLLUTION
MAN
METABOLISM
OCCUPATIONAL EXPOSURE
AIR POLLUTION
ANIMALS
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
POLLUTION
PRIMATES
SYNTHESIS
VERTEBRATES
540120* - Environment
Atmospheric- Chemicals Monitoring & Transport- (1990-)
560300 - Chemicals Metabolism & Toxicology