Antimutagenic properties of WR 2721 and of a radioprotective mixture, ATP-AET-serotonin, with regard to X ray induced reciprocal translocations in mouse spermatogonia

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(87)90268-9· OSTI ID:6700258

Benova, D

Pretreatment by intraperitoneal administration of WR 2721 at 400 mg/kg body weight in mice receiving 4.0 Gy X rays was found to have an appreciable antimutagenic effect with regard to reciprocal translocation induction in spermatogonia. The effectiveness of the product tested proved superior to that of a radioprotective mixture of ATP-AET-serotonin given at optimal dose ratio--360, 24, and 8 mg/kg body weight, respectively. The RF (Reduction Factor) was 2.4 for WR 2721 and 1.8 for the mixture. The effect observed indicated WR 2721 to have potential capabilities for reducing the genetic risk of radiation in male individuals.

• Research Organization: Medical Academy Institute of Roentgenology and Radiobiology, Sofia, Bulgaria
• OSTI ID: 6700258
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AET
RADIOSENSITIVITY EFFECTS
SEROTONIN
GENETIC RADIATION EFFECTS
MICE
RADIATION PROTECTION
SPERMATOGONIA
SPERMATOZOA
X RADIATION
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBONIC ACID DERIVATIVES
DRUGS
ELECTROMAGNETIC RADIATION
GAMETES
GENETIC EFFECTS
GERM CELLS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
IONIZING RADIATIONS
MAMMALS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PYRROLES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RODENTS
SYMPATHOMIMETICS
THIOUREAS
TRYPTAMINES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals