Inhalation toxicology of fog-oil obscurant. Final report, October 1981-February 1986
Sixty-day-old, male and female rats were exposed by inhalation to fog-oil smoke. Mortality, LC50, subacute, and subchronic studies were performed. Mortality studies showed fog-oil smoke to be 100% lethal at 11.0 mg/L, 95% lethal at 5.0 mg/L, 20% lethal at 1.0 mg/L, and 0% lethal at 0.1 mg/L after a 6-hour exposure. The observed LC50 of fog-oil smoke after a 3.5-hr exposure was 5.2 mg/L. In the subacute and subchronic studies, rats were exposed to air, 0.2-, 0.5-, or 1.5-mg/L fog oil smoke for 3.5 hr/day, 4 days/wk for either 4 of 13 wk. Both pulmonary and systemic effects were investigated one day after the exposure ceased. For one 13-wk exposure group, animals were also examined 4 wk after the exposure. Following the subacute 4-exposure to 1.5 mg/L, a multifocal pneumonitis was observed. Lung lavage had an elevated number of polymorphonuclear leukoctes (PMNs), alveolar macrophages, and lung weights was observed after exposure to 0.5 mg/L. Pulmonary-function tests revealed an increase in end expiratory volume (EEV) after 1.5mg/L. Systemic effects after the subacute exposure were minimal. A decrease in zoxazolamine-induced paralysis time was observed following both 0.5 and 1.5 mg/L; however, no effect on pentobarbital-induced sleeping time was observed. Behavioral studies were negative, as were clinical chemistries and immune function tests.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Inhalation Toxicology Div.
- OSTI ID:
- 6699491
- Report Number(s):
- AD-A-176106/3/XAB
- Country of Publication:
- United States
- Language:
- English
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FOG
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TOXICITY
SMOKES
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FEMALES
INHALATION
PHAGOCYTES
PNEUMONIA
RATS
RETICULOENDOTHELIAL SYSTEM
WEIGHT
AEROSOLS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
COLLOIDS
DISEASES
DISPERSIONS
FLUIDS
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INTAKE
MAMMALS
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OTHER ORGANIC COMPOUNDS
RESIDUES
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RODENTS
SOLS
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560300* - Chemicals Metabolism & Toxicology