Dual head HIPDM SPECT imaging in the differential diagnosis of dementia with MR and CT correlation

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6699313

Wellman, H N; Gilmor, R; Hendrie, H; Mock, B; Kapuscinski, A; Appledorn, C R; Krepshaw, J

Dual head SPECT brain imaging was performed in 25 patients with a clinical diagnosis of dementia approximately one-half hour after a 5mCi dose of high purity (p,5n) I-123 HIPDM (N,N,N'-Trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)- 1,3-propane diamine). Tomographic reconstruction used a 30th order, moderate cutoff (0.2) Butterworth filter found previously to optimize low noise and conspicuity. Most patients had CT and MR imaging and some patients were studied more than once. In approximately one-half of patients referred with a diagnosis of dementia of the Alzheimer's type, SPECT results were consistent with multiple infarct dementia (MID). MR studies in most of these patients with MID demonstrated multiple white matter defects correlating with multiple gray matter defects seen with SPECT and consistent with angiogenic disease of the Binswanger's type. While CT demonstrated cortical abnormalities in some patients, the findings were often nonspecific with enlarged ventricles and widened sulci.

• Research Organization: Indiana Univ. School of Medicine, Indianapolis, IN
• OSTI ID: 6699313
• Report Number(s): CONF-850611-
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
AMINES
CHEMICAL COMPOSITION
DIAGNOSTIC USES
LABELLING
BRAIN
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
IODINE 123
NERVOUS SYSTEM DISEASES
DIAGNOSIS
DEFECTS
DIAGNOSTIC TECHNIQUES
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MAGNETIC RESONANCE
MENTAL DISORDERS
NEUROLOGY
PATIENTS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
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ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RESONANCE
TOMOGRAPHY
USES
550602* - Medicine- External Radiation in Diagnostics- (1980-)
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