Genotoxicity studies of methyl isocyanate in Salmonella, Drosophila, and cultured Chinese hamster ovary cells

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860090104· OSTI ID:6698851

Mason, J M; Zeiger, E; Haworth, S; Ivett, J; Valencia, R

The genotoxic effects of methyl isocyanate (MIC) were investigated using four short-term tests: the Salmonella reversion assay (Ames test), the Drosophila sex-linked recessive lethal assay, and the sister chromatic exchange (SCE) and chromosomal aberration assays in cultured Chinese hamster ovary (CHO) cells. No evidence was found for the induction of mutations in either Salmonella or Drosophila. MIC did, however, induce SCEs and chromosomal aberrations in CHO cells both in the presence and absence of Aroclor-induced rat liver S-9.

• Research Organization: National Institute of Environmental Health Sciences, Research Triangle Park, NC
• OSTI ID: 6698851
• Journal Information: Environ. Mutagen.; (United States), Vol. 9:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ISOCYANATES
GENETIC EFFECTS
MUTAGEN SCREENING
CHO CELLS
CHROMOSOMAL ABERRATIONS
DROSOPHILA
LIVER
METABOLIC ACTIVATION
RATS
SALMONELLA TYPHIMURIUM
SISTER CHROMATID EXCHANGES
ANIMAL CELLS
ANIMALS
ARTHROPODS
BACTERIA
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DIPTERA
FLIES
FRUIT FLIES
GLANDS
INSECTS
INVERTEBRATES
MAMMALS
MICROORGANISMS
MUTATIONS
ORGANS
RODENTS
SALMONELLA
SCREENING
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology