Regional assignment of the human homebox-containing gene EN1 to chromosome 2q13-q21

Journal Article · Fri Jan 01 00:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1045· OSTI ID:6697205

Koehler, A; Muenke, M ^[1]; Logan, C ^[2]; Joyner, A L ^[3]

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1. Univ. of Pennsylvania, Philadelphia (United States)
2. Univ. of Toronto (Canada)
3. Univ. of Toronto (Canada) Samuel Lunenfeld Research Institute, Toronto (Canada)

The human homeobox-containing genes EN1 and EN2 are closely related to the Drosophila pattern formation gene engrailed (en), which may be important in brain development, as shown by gene expression studies during mouse embryogenesis. Here, we have refined the localization of EN1 to human chromosome 2q13-q21 using a mapping panel of rodent/human cell hybrids containing different regions of chromosome 2 and a lymphoblastoid cell line with an interstitial deletion, del(2) (q21-q23.2). This regional assignment of EN1 increases to 22 the number of currently known genes on human chromosome 2q that have homologs on the proximal region of mouse chromosome 1. 15 refs., 2 figs.

• OSTI ID: 6697205
• Journal Information: Genomics; (United States), Vol. 15:1; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANIMAL GROWTH
CONTROL
GENES
HUMAN CHROMOSOME 2
GENETIC MAPPING
BRAIN
DROSOPHILA
ANIMALS
ARTHROPODS
BODY
CENTRAL NERVOUS SYSTEM
CHROMOSOMES
DIPTERA
FLIES
FRUIT FLIES
GROWTH
HUMAN CHROMOSOMES
INSECTS
INVERTEBRATES
MAPPING
NERVOUS SYSTEM
ORGANS
550400* - Genetics