Increased cerebral blood flow during hypercapnia is not affected by lesion of the nucleus locus ceruleus

Journal Article · Sat Nov 01 00:00:00 EST 1986 · Stroke; (United States)

DOI:https://doi.org/10.1161/01.STR.17.6.1235· OSTI ID:6695991

Harik, S I; Prado, R; Busto, R; Ginsberg, M D

To test the hypothesis that the putative noradrenergic innervation of intraparenchymal cerebral blood vessels from the nucleus locus ceruleus mediates the vasodilatory response to hypercapnia, regional cerebral blood flow was measured by iodo-(/sup 14/C)antipyrine autoradiography in awake and restrained rats with unilateral 6-hydroxydopamine lesion of the nucleus locus ceruleus and in unlesioned control rats. Hypercapnia, induced by the inhalation of 5% or 8% CO/sub 2/ in air for 8 minutes caused a 2 to 5-fold increase in regional cerebral blood flow. However, despite a marked reduction of about 90% in cortical norepinephrine levels ipsilateral to the lesion, blood flow to the frontal and parietal cortex, hippocampus, striatum and cerebellum increased to the same extent in ipsilateral and contralateral regions. Thus, lesion of the locus ceruleus and the resultant depletion of endogenous cortical and hippocampal norepinephrine, does not influence the cerebrovascular response to hypercapnia.

• Research Organization: Univ. Hospitals of Cleveland, OH
• OSTI ID: 6695991
• Journal Information: Stroke; (United States), Vol. 6
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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AUTORADIOGRAPHY
BLOOD FLOW
CARBON DIOXIDE
BIOLOGICAL EFFECTS
ANTIPYRINE
CARBON 14 COMPOUNDS
CEREBRAL ARTERIES
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AUTONOMIC NERVOUS SYSTEM AGENTS
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CARDIOTONICS
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CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHALCOGENIDES
DRUGS
HETEROCYCLIC COMPOUNDS
HORMONES
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PYRAZOLES
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STEROID HORMONES
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