DNA damage and repair in human skin: Pathways and questions

Conference · Sun Jan 01 00:00:00 EST 1989

OSTI ID:6693404

Sutherland, B M; Hacham, H; Sutherland, J C ^[1]; Gange, R W; Maytum, D ^[2]

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1. Brookhaven National Lab., Upton, NY (USA)
2. Harvard Medical School, Boston, MA (USA). Dept. of Dermatology

Skin is assaulted daily with physical and chemical carcinogens, promoters, and modifiers of biological responses to such agents. DNA is the principal target for most carcinogens, and DNA in skin is particularly at risk. It is subject to damage not only from ingested compounds and their metabolic products, but also from externally applied or encountered chemicals, as well as from physical carcinogens such as sunlight and cosmetic or medical source of ultraviolet radiation. Three major factors determine the balance between damage to DNA of skin and the biological consequences of that damage: the frequencies and types of lesions, the ability of the individual to repair a lesion, and the strategy that skin employs to deal with the different spectra of lesions inflicted under varying environmental conditions. Thus, cellular responses to DNA damage, including repair of DNA lesions, are critical factors in determining the final level of damage and its consequences. This paper discusses DNA damage and repair in human skin. 35 refs.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6693404
• Report Number(s): BNL-44839; CONF-8910354-2; BIO-4595; ON: DE90015126
• Resource Relation: Conference: DNA damage and repair in human tissues conference, Upton, NY (USA), 1-4 Oct 1989
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CARCINOGENS
BIOLOGICAL EFFECTS
DNA
DAMAGE
FIBROBLASTS
DNA REPAIR
SKIN
BIOLOGICAL PATHWAYS
EXCISION REPAIR
LABELLING
MAN
ULTRAVIOLET RADIATION
VISIBLE RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
MAMMALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIATIONS
RECOVERY
REPAIR
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550200 - Biochemistry