Myocardial imaging with a radioiodinated norepinephrine storage analog
Meta-iodobenzylguanidine (M-IBG), an iodinated aromatic analog of the hypotensive drug guanethidine, localizes in the heart of the rat, dog, and rhesus monkey. A comparative study of tissue distribution in the dog has been performed with five myocardiophilic agents: thallium-201, I-125 16-iodohexadecanoic acid, H-3 norepinephrine, C-14 guanethidine and I-125 M-IBG. The last two compounds give heart concentrations and heart-to-blood concentration ratios similar to those of thallium-201. Planar and tomographic images of the hearts of the dog and rhesus monkey were obtained using I-131 or I-123 labeled M-IBG. Blocking studies with reserpine suggest that a major component of myocardial retention of M-IBG is sequestration within the norepinephrine storage vesicles of the adrenergic nerves. The localization of M-IBG in other organs with rich sympathetic innervation and the relative insensitivity of myocardial uptake to a wide range of loading doses lend additional support for a neuronal mode of retention.
- Research Organization:
- Univ. of Michigan Medical Center, Ann Arbor
- DOE Contract Number:
- EY-76-S-02-2031
- OSTI ID:
- 6689199
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 22:1; Conference: 28. annual meeting of Society of Nuclear Medicine, Las Vegas, NV, USA, 16 Jun 1981
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CARBON 14
DIAGNOSTIC USES
GUANIDINES
IODINE 125
IODINE 131
MYOCARDIUM
SCINTISCANNING
THALLIUM 201
TRITIUM
BIOLOGICAL LOCALIZATION
COMPARATIVE EVALUATIONS
DOGS
LABELLED COMPOUNDS
MACACUS
NERVES
RADIATION DOSES
RADIONUCLIDE KINETICS
RATS
RETENTION
TISSUE DISTRIBUTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CARBONIC ACID DERIVATIVES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOSES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
HEART
HEAVY NUCLEI
HYDROGEN ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MONKEYS
MUSCLES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques