Genital condyloma virus infection following pelvic radiation therapy: report of seven cases

Journal Article · Sat Jan 01 00:00:00 EST 1983 · Int. J. Gynecol. Pathol.; (United States)

DOI:https://doi.org/10.1097/00004347-198303000-00007· OSTI ID:6678871

Lowell, D M; Livolsi, V A; Ludwig, M E

Six women who underwent radiation therapy for gynecologic malignancies demonstrated cytologic evidence of condyloma virus infection 2 or more years following radiation. Histologic confirmation was obtained in two of the cases. A seventh patient developed in situ and invasive squamous cell carcinoma in a vulvar condyloma acuminatum following radiation therapy for Hodgkin's disease. This venereal infection is found most frequently in sexually active younger women (average age, 27 years). It is felt that depressed cell-mediated immunity consequent to the radiation therapy allowed the development of this infection in the older patients described in this report. The evolution of invasive squamous cell carcinoma in the condyloma acuminatum may indicate a possible oncogenic or cocarcinogenic effect of the virus. The immunologic responses to infection caused by the human papillomavirus group are discussed, as well as its potential for malignant transformation.

• Research Organization: Waterbury Hospital, CT
• OSTI ID: 6678871
• Journal Information: Int. J. Gynecol. Pathol.; (United States), Vol. 2:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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HODGKINS DISEASE
RADIOTHERAPY
NEOPLASMS
SIDE EFFECTS
VIRUSES
INFECTIVITY
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RADIOLOGY
THERAPY
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