Lateral high abdominal ovariopexy: an original surgical technique for protection of the ovaries during curative radiotherapy for Hodgkin's disease
An original surgical method for gonadal protection in young women given pelvic radiation for Hodgkin's disease is presented. Lateral high ovarian transposition (LHAO) consists of the transposition of the ovaries into the paracolic gutter during staging laparotomy, after disconnecting the gonads from the fallopian tubes by dividing the tubo-ovarian vessels. The technique's effectiveness was assessed by a study using clinical investigation, radioimmunoassay (RIA) determination of sex hormones, and dosimetry; of 18 patients treated, 10 participated in the study. All but one have normal menses and hormone values, and one pregnancy occurred. We also calculated the doses absorbed by the ovaries and proved that, during inverted Y irradiation following LHAO, the ovaries are exposed to nearly one-half the dose they receive after traditional medial transposition. During subtotal nodal irradiation after LHAO, the irradiation dose is higher than after medialisation, but absolute values are minimal and castration is not induced.
- Research Organization:
- Univ. of Turin (Italy)
- OSTI ID:
- 6677854
- Journal Information:
- J. Surg. Oncol.; (United States), Vol. 39:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HODGKINS DISEASE
RADIOTHERAPY
OVARIES
RADIATION PROTECTION
PELVIS
IRRADIATION
MENSTRUAL CYCLE
PATIENTS
RADIATION DOSES
RADIATION INJURIES
RADIOIMMUNOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DISEASES
DOSES
FEMALE GENITALS
GONADS
IMMUNE SYSTEM DISEASES
IMMUNOASSAY
IMMUNOLOGY
INJURIES
ISOTOPE APPLICATIONS
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOASSAY
RADIOIMMUNOLOGY
RADIOLOGY
THERAPY
TRACER TECHNIQUES
560151* - Radiation Effects on Animals- Man