Susceptibility to virus infection with exposure to nitrogen dioxide. Research report, January 1984-July 1987
The interaction between nitrogen dioxide (NO/sub 2/) exposure and human susceptibility to respiratory virus infection was investigated in a placebo-controlled, randomized, blinded trial conducted in an environmentally controlled research chamber. Healthy, nonsmoking volunteers, 18 to 35 years old, who were seronegative to influenza A/Korea/82 (H/sub 3/N/sub 2/) virus, breathed either filtered air or NO/sub 2/ for two hours a day for three consecutive days. Live, attenuated cold-adapted influenza A/Korea/82 reassortant virus was administered intranasally to all subjects after the second day of exposure. No adverse changes in pulmonary function or nonspecific airway reaction to methacholine were observed after NO/sub 2/ exposure, virus infection, or both. Although the differences were not statistically significant, the groups exposed to NO/sub 2/ in year 3 became infected more often (91%) than those exposed only to air (71%).
- Research Organization:
- Health Effects Inst., Cambridge, MA (USA)
- OSTI ID:
- 6677057
- Report Number(s):
- PB-88-234463/XAB; HEI/RR-88/15
- Resource Relation:
- Other Information: See also PB--88-234455
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
54 ENVIRONMENTAL SCIENCES
INFECTIOUS DISEASES
NITROGEN DIOXIDE
BIOLOGICAL EFFECTS
VIRAL DISEASES
AIR POLLUTION
PROGRESS REPORT
CHALCOGENIDES
DISEASES
DOCUMENT TYPES
NITROGEN COMPOUNDS
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
POLLUTION
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)