Changes in cerebral blood flow in patients with severe congestive cardiac failure before and after captopril treatment
The intravenous /sup 133/xenon injection method was used to estimate global cerebral blood flow before and after treatment with captopril in nine patients with severe heart failure. The pretreatment mean blood pressure was 94.9 mm Hg (S.D. 13.9) and fell to 85.1 mm Hg (S.D. 18.1) after treatment with captopril for between four and 15 days. The cerebral blood flow before captopril was 61.1 ml/100 g per minute (S.D. 6.9), which was less than the value of 75.8 ml/100 g per minute found in control subjects. After treatment with captopril the cerebral blood flow increased to 73.8 ml/100 g per minute (S.D. 11.8, p less than 0.01). The fraction of carbon dioxide in the expired air was not significantly different in the two studies (4.1 +/- 0.88 versus 3.97 +/- 0.65). It is concluded that cerebral blood flow is reduced in severe heart failure and can be restored by treatment with captopril, but the reasons for the reduced flow and its improvement after converting enzyme inhibition are not known.
- Research Organization:
- Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, England
- OSTI ID:
- 6670048
- Journal Information:
- Am. J. Med.; (United States), Vol. 76:5B
- Country of Publication:
- United States
- Language:
- English
Similar Records
Hemodynamic and radionuclide effects of acute captopril therapy for heart failure: changes in left and right ventricular volumes and function at rest and during exercise
Hemodynamic and radionuclide effects of acute captopril therapy for heart failure: changes in left and right ventricular volumes and function at rest and during exercise
Related Subjects
BRAIN
BLOOD FLOW
CARDIOVASCULAR DISEASES
PATHOGENESIS
ENZYME INHIBITORS
BIOLOGICAL EFFECTS
INHALATION
PATIENTS
TRACER TECHNIQUES
XENON 133
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics