Changes in airway permeability and responsiveness after exposure to ozone. [Sheep]

Journal Article · Fri Jun 01 00:00:00 EDT 1984 · Environ. Res.; (United States)

OSTI ID:6665819

Abraham, W M; Delehunt, J C; Yerger, L; Marchette, B; Oliver, W Jr

The relationship between airway responsiveness and the permeability of histamine through the airways in conscious sheep after exposure to ozone (O/sub 3/ was examined). Airway responsiveness was assessed by measuring the change from baseline in mean pulmonary flow resistance following a controlled 2-min inhalation challenge with 1% histamine, containing 200 ..mu..Ci/ml of (/sup 3/H)histamine. The rate of appearance of the (/sup 3/H)histamine in the plasma during inhalation challenge was used to estimate airway permeability. To perturb the airways, conscious sheep were exposed to either 0.5 or 1.0 ppm O/sub 3/ for 2 hr via an endotracheal tube. Airway responsiveness and airway permeability were measured prior to and 1 day after exposure. In six sheep exposed to 0.5 ppm O/sub 3/, increased airway responsiveness and airway permeability were obseved 1 day after exposure. Four of seven sheep exposed to 1.0 ppm O/sub 3/ had enhanced airway responsiveness and airway permeability, while the remaining three sheep showed corresponding decreases in airway responsiveness and airway permeability. Since the O/sub 3/-induced directional changes in airway responsiveness paralleled the directional changes in airway permeability in both the positive and negative directions, it was concluded that changes in airway responsiveness to inhaled histamine following exposure to O/sub 3/ may be related to concomitant changes in airway permeability to this agent.

• Research Organization: Mount Sinai Medical Center, Miami Beach, FL
• OSTI ID: 6665819
• Journal Information: Environ. Res.; (United States), Vol. 34:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
EPITHELIUM
PERMEABILITY
HISTAMINE
BIOLOGICAL EFFECTS
OZONE
RESPIRATORY SYSTEM
AIR FLOW
INHALATION
LABELLED COMPOUNDS
SHEEP
TRITIUM COMPOUNDS
AMINES
ANIMAL TISSUES
ANIMALS
AZOLES
BODY
DOMESTIC ANIMALS
FLUID FLOW
GAS FLOW
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INTAKE
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RUMINANTS
TISSUES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)