Bone sarcoma as a second malignant neoplasm in children: influence of radiation and genetic predisposition

Journal Article · Mon Dec 15 00:00:00 EST 1980 · Cancer; (United States)

DOI:https://doi.org/10.1002/1097-0142(19801215)46:12<2603::AID-CNCR2820461212>3.0.CO;2-4· OSTI ID:6664276

Meadows, A T; Strong, L C; Li, F P; D'angio, G J; Schweisguth, O; Freeman, A I; Jenkin, R D.T.; Morris-Jones, P; Nesbit, M E

Osteosarcoma or chondrosarcoma developed as a second malignant neoplasm (SMN) in 40 of 188 individuals with SMN whose first neoplasm occurred in childhood. A genetic susceptibility to cancer was found in 23; the SMN developed in an irradiated field in 32; both factors were present in 16; neither in one. When a genetic predisposition was present, radiation shortened the interval to SMN. The intervals between tumors and the age at which the bone sarcomas developed in relation to genetic disease and therapy were analyzed by a two-mutation hypothesis.

• Research Organization: Children's Hospital of Philadelphia, PA
• OSTI ID: 6664276
• Journal Information: Cancer; (United States), Vol. 46:12
• Country of Publication: United States
• Language: English

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