A pulsed-field gel electrophoresis (PFGE) map of twelve loci on chromosome 11q11-q13
- Yale Univ. School of Medicine, New Haven, CT (United States)
- Massachusetts General Hospital and Harvard Medical School, Boston (United States)
- National Inst. of Diabetes and Digestive and Kidney Diseases, Bethesda, MD (United States)
We report a pulsed-field gel electrophoresis map of 12 loci on proximal human chromosome 11q. Linkage studies have shown that this region of chromosome 11 contains the genes for familial atopic disease (APY) and multiple endocrine neoplasia type I (MEN1) (4). A physical map containing polymorphic loci will aid in the isolation of these disease genes. The map reported here has two noncontiguous groups of loci accounting for 8 of the 12 loci evaluated. One group spans a maximum distance of 1600 kb and included D11S146, BCL1, PRAD1, INT2, and HSTF1. The other group includes FTY1, C1NH, and COX8. TCN1, PGA, and PYGM did not yield any comigrating fragments and could not be physically linked on this PFGE map. These data enhance previously published physical maps of proximal 11q by refining the localization of and distances between markers in the BCL1 region. Additionally, new information about the locations and physical relationships between FTH1, C1NH, and COX 8 is presented. 14 refs., 3 figs.
- OSTI ID:
- 6660192
- Journal Information:
- Genomics; (United States), Vol. 15:2; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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