Physiological responses wearing MOPP-IV after atropine and pralidoxime administration in warm and cool environments
The effect of cholinolytic and oxime (2 mg atropine + 600 mg pralidoxime) therapy on temperature regulation was evaluated in 8 subjects wearing chemical warfare protective clothing (MOPP-level IV). Subjects were tested in two environments: 35 c, 60% rh and 13 C, 44% rh during very light physical activity (1-2 Met) over a six-hour period. Sweating was suppressed approximately 40% by atropine and pralidoxime, and heart rate increased approximately 30 beats/min with drug treatment. At 13 C, all eight subjects completed 350 minutes of exposure in both drug and control experiments. Rectal temperature (t sub re) averaged 38.24 C in both treatments when subjects terminated their exposure at 35 C. Mean skin temperature averaged 37.42 C for both groups at termination. The treatment of subjects with atropine and pralidoxime when wearing chemical protective clothing does not adversely affect the length of time individuals can remain in a cool environment during very light work. However, the wearing of chemical protective clothing will decrease exposure time significantly (approx. 40%) in both control and drug treated subjects in a warm environment.
- Research Organization:
- Army Research Inst. of Environmental Medicine, Natick, MA (USA)
- OSTI ID:
- 6660086
- Report Number(s):
- AD-A-197703/2/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHEMICAL WARFARE
PROTECTIVE CLOTHING
DRUGS
RESPONSE MODIFYING FACTORS
EVALUATION
ATROPINE
BODY TEMPERATURE
HEAT
HUMAN FACTORS ENGINEERING
OXIMES
PARASYMPATHOLYTICS
RECTUM
ALKALOIDS
AMINES
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CLOTHING
DIGESTIVE SYSTEM
ENERGY
ENGINEERING
GASTROINTESTINAL TRACT
HYDROXY COMPOUNDS
INTESTINES
LARGE INTESTINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
WARFARE
420202* - Engineering- Protective Structures & Equipment