A toxological study of 3,6-BIS(3,5-Dimethyl-1-1-Pyrazolyl)1,2-Dihydro-1,2,4,5-Tetrazine
Abstract
The acute oral LD[sub 30/50] values for 3,6-BIS(3,5-Dimethyl-1-Pyrazolyl)-1,2-Dihydro-1,2,4,5-Tetrazine BIS(DMP)DHT are greater than 5g/kg. According to classical guidelines, the material would be considered only slightly toxic or practically nontoxic in both rats and mice. The sensitization study in the guinea pig did not show BIS(DMP)SHT to have potential sensitizing effects. Skin application studies on the rabbit demonstrated the material was cutaneously nonirritating. This material was also nonirritating in the rabbit eye application studies.
- Authors:
- Publication Date:
- Research Org.:
- Los Alamos National Lab., NM (United States)
- Sponsoring Org.:
- USDOE; USDOE, Washington, DC (United States)
- OSTI Identifier:
- 6657861
- Report Number(s):
- LA-12347-MS
ON: DE93009115
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Technical Report
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE; AZINES; TOXICITY; CHEMICAL EXPLOSIVES; EYES; MICE; ORAL ADMINISTRATION; RABBITS; RATS; SKIN ABSORPTION; ABSORPTION; ANIMALS; BODY; BODY AREAS; EXPLOSIVES; FACE; HEAD; HETEROCYCLIC COMPOUNDS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RODENTS; SENSE ORGANS; SORPTION; UPTAKE; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology; 450100 - Military Technology, Weaponry, & National Defense- Chemical Explosions & Explosives
Citation Formats
London, J E. A toxological study of 3,6-BIS(3,5-Dimethyl-1-1-Pyrazolyl)1,2-Dihydro-1,2,4,5-Tetrazine. United States: N. p., 1993.
Web.
London, J E. A toxological study of 3,6-BIS(3,5-Dimethyl-1-1-Pyrazolyl)1,2-Dihydro-1,2,4,5-Tetrazine. United States.
London, J E. 1993.
"A toxological study of 3,6-BIS(3,5-Dimethyl-1-1-Pyrazolyl)1,2-Dihydro-1,2,4,5-Tetrazine". United States.
@article{osti_6657861,
title = {A toxological study of 3,6-BIS(3,5-Dimethyl-1-1-Pyrazolyl)1,2-Dihydro-1,2,4,5-Tetrazine},
author = {London, J E},
abstractNote = {The acute oral LD[sub 30/50] values for 3,6-BIS(3,5-Dimethyl-1-Pyrazolyl)-1,2-Dihydro-1,2,4,5-Tetrazine BIS(DMP)DHT are greater than 5g/kg. According to classical guidelines, the material would be considered only slightly toxic or practically nontoxic in both rats and mice. The sensitization study in the guinea pig did not show BIS(DMP)SHT to have potential sensitizing effects. Skin application studies on the rabbit demonstrated the material was cutaneously nonirritating. This material was also nonirritating in the rabbit eye application studies.},
doi = {},
url = {https://www.osti.gov/biblio/6657861},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Mar 01 00:00:00 EST 1993},
month = {Mon Mar 01 00:00:00 EST 1993}
}
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