Usefulness of bone marrow imaging in childhood malignancies

Journal Article · Sun Aug 01 00:00:00 EDT 1982 · J. Pediatr.; (United States)

DOI:https://doi.org/10.1016/S0022-3476(82)80118-2· OSTI ID:6656615

Oseas, R S; Siddiqui, A R; Wellman, H N; Baehner, R L

Two hundred six /sup 99m/Tc sulfur colloid bone marrow scans in 110 pediatrics patients were reviewed. The normal distribution of sulfur colloid in the lower extremities in various age groups was established. There was progressive loss of uptake with increasing age from less than two years to greater than ten years. Tumor replacement was seen as regions of decreased radioactivity, and the extent of the scan defect paralleled the response of the disease to therapy. Both chemotherapy and irradiation resulted in an extension of the /sup 99m/Tc SC to peripheral marrow sites. In irradiated areas, marrow scan defects were demonstrated and generally recovered normal activity by six months after the completion of therapy. Marrow scan abnormalities caused by tumor replacement were present in four patients despite normal bone scans and radiographs. Ultimate confirmation of tumor involvement was by needle aspiration or biopsy. Persistent marrow defects were seen in two patients with neuroblastoma who had remission of their disease: biopsy revealed myelofibrosis. /sup 99m/Tc sulfur colloid bone marrow scanning is a sensitive monitor of altered marrow activity associated with pediatric hematologic or oncologic diseases.

• Research Organization: Department of Pediatrics, Division of Hematology/Oncology and Radiology, James Whitcomb Riley Hospital for Children, Indianapolis, IN
• OSTI ID: 6656615
• Journal Information: J. Pediatr.; (United States), Vol. 101:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
SKELETAL DISEASES
DIAGNOSIS
SKELETON
SCINTISCANNING
TECHNETIUM 99
DIAGNOSTIC USES
AGE DEPENDENCE
CHEMOTHERAPY
ISOMERIC NUCLEI
LOCAL IRRADIATION
PATHOLOGY
PATIENTS
PEDIATRICS
RADIOCOLLOIDS
UPTAKE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
THERAPY
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
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