A study of the distribution of schistosomicidal drug H-3-7505 in mice

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6654547

Hao, T

The authors have studied the distribution of H-3 labelled schistosomicidal drug in mice by autoradiography. The H-3-labelled substances were found in liver and kidney and in successfully decreasing amounts in brain, lung, heart, fat, testis, pancreas and spleen. In various cells the silver granules were present mainly in the cytoplasms but a few in the nucleus. After administration of this labelled schistosomicidal drug, the mice were killed and studied in groups successively at 4, 8, 24 hrs. No difference in the distribution of silver granules were observed. This fact indicated that, this drug was rapidly absorbed and highly concentrated with a long duration of reservation in liver. All of these favours the schistosomicidal effect of the drug. As this drug was highly concentrated in the cytoplasm of liver cells, that might provide a pathophysiologic basis for the explanation of jaundice in the clinical practice. Moreover, the appearance of toxic reaction in nervous system may be related to the relatively high concentration of the drug distributed in the brain.

• Research Organization: Dept. of Nuclear Medicine, Hubei Medical College
• OSTI ID: 6654547
• Report Number(s): CONF-850611-; TRN: 87-015088
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTI-INFECTIVE AGENTS
TISSUE DISTRIBUTION
UPTAKE
JAUNDICE
DIAGNOSIS
KIDNEYS
AUTORADIOGRAPHY
LIVER
BRAIN
DOSE-RESPONSE RELATIONSHIPS
FATS
HEART
LABELLED COMPOUNDS
LUNGS
MICE
PANCREAS
SPLEEN
TESTES
TIME DEPENDENCE
TRACER TECHNIQUES
ANIMALS
BODY
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ENDOCRINE GLANDS
GLANDS
GONADS
ISOTOPE APPLICATIONS
MALE GENITALS
MAMMALS
NERVOUS SYSTEM
ORGANS
PATHOLOGICAL CHANGES
RESPIRATORY SYSTEM
RODENTS
SYMPTOMS
VERTEBRATES
550501* - Metabolism- Tracer Techniques