Stannous glucoheptonate: An effective tinning agent for Tc-99m labeling of blood cells

Conference · Wed Jan 01 00:00:00 EST 1986

OSTI ID:6654406

Straub, R F; Meinken, G E; Srivastava, S C

Of the various tin compounds studied, stannous glucoheptonate proved to be the most effective tinning agent for labelling blood cells with technetium 99. Much less tin was needed to achieve a rapid and satisfactory intracellular Sn(II) content. Less Sn(II) remained extracellular, facilitating its removal by oxidation or washing. Highest /sup 99m/Tc-labeling efficiencies are obtained for RBC, leukocytes, and platelets. Label stability in vitro was higher (2 to 3% washout from /sup 99m/Tc-RBC, and approx. 10% from /sup 99m/Tc-leukocytes and platelets, upon prolonged incubation with saline or plasma). The order of effectiveness for the tinning agents tested is glucoheptonate > citrate >> DTPA > PYP. 4 refs., 6 figs.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6654406
• Report Number(s): BNL-38482; CONF-860627-3; ON: DE87008204
• Resource Relation: Conference: 33. annual meeting of the Society of Nuclear Medicine, Washington, DC, USA, 22 Jun 1986; Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
ERYTHROCYTES
LABELLING
TECHNETIUM 99
MEMBRANE TRANSPORT
MONOSACCHARIDES
TIN COMPOUNDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
SACCHARIDES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials