Assignment of the gene encoding glycogen synthase (GYS) to human chromosome 19, band q13,3

Journal Article · Mon Feb 01 00:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1092· OSTI ID:6652786

Lehto, M ^[1]; Stoffel, M; Espinosa, R III; Beau, M.M. le; Bell, G I ^[2]; Groop, L ^[3]

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1. Univ. of Chicago, IL (United States) Helsinki Univ. (Finland)
2. Univ. of Chicago, IL (United States)
3. Helsinki Univ. (Finland)

The enzyme glycogen synthase (UDP glocose:glycogen 4-[alpha]-D-glucosyltransferase, EC 2.4.1.11) catalyzes the formation of glycogen from uridine diphosphate glucose (UPDG). Impaired activation of muscle glycogen synthase by insulin has been noted in patients with genetic risk of developing non-insulin-dependent diabets mellitus (NIDDM) and this may represent an early defect in the pathogenesis of this disorder. As such, glycogen synthase represents a candidate gene for contributing to genetic susceptibility. As a first step in studying the role of glycogen synthase in the genetics of NIDDM, we have isolated a cosmid encoding the human glycogen synthase gene (gene symbol GYS) and determined its chromosomal localization by fluorescence in situ hybridization. 4 refs., 1 fig.

• OSTI ID: 6652786
• Journal Information: Genomics; (United States), Vol. 15:2; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DIABETES MELLITUS
PATHOGENESIS
GLYCOGEN
SYNTHESIS
HUMAN CHROMOSOME 19
GENETIC MAPPING
ENZYMES
FLUORESCENCE
GENETICS
GLUCOSE
HYBRIDIZATION
INSULIN
PATIENTS
URIDINE
ALDEHYDES
AZINES
BIOLOGY
CARBOHYDRATES
CHROMOSOMES
DISEASES
ENDOCRINE DISEASES
HETEROCYCLIC COMPOUNDS
HEXOSES
HORMONES
HUMAN CHROMOSOMES
HYDROXY COMPOUNDS
LUMINESCENCE
MAPPING
METABOLIC DISEASES
MONOSACCHARIDES
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PEPTIDE HORMONES
POLYSACCHARIDES
PROTEINS
PYRIMIDINES
RIBOSIDES
SACCHARIDES
URACILS
550400* - Genetics