( sup 14 C)urea breath test for diagnosis of Helicobacter pylori
Abstract
H. pylori is a potent urease producer, a characteristic that has been exploited in the development of the (14C)- and (13C)urea breath tests. The prevalence of H. pylori infection also is known to increase with advancing age; however, the individual patient's age has not routinely been considered when interpreting urea breath test results. The aim of this study was to validate a short, age-adjusted (14C)urea breath test for use in diagnosing H. pylori infections. Forty-one subjects (28 volunteers, 13 patients) underwent esophagogastroduodenoscopy with biopsies. Subjects were defined as being H. pylori-positive if histology or culture was positive. In addition, all subjects completed a 120-min (14C)urea breath test. A logistic regression analysis adjusting for age was used to estimate the probability of H. pylori positivity as a function of the 14C values generated. Sixteen subjects were H. pylori-positive, and 25 were H. pylori-negative. The 14C values generated between 15 and 80 min were found to be equally predictive in identifying H. pylori-positive subjects. Advancing age was associated with a higher probability of H. pylori-positivity. By taking advantage of the statistical probabilities, older patients could be accurately diagnosed with H. pylori at lower 14C values. We found that (14C)urea breath test tomore »
- Authors:
-
- Mayo Clinic, Rochester, MN (USA)
- Publication Date:
- OSTI Identifier:
- 6648487
- Resource Type:
- Journal Article
- Journal Name:
- Digestive Diseases and Sciences; (USA)
- Additional Journal Information:
- Journal Volume: 35:7; Journal ID: ISSN 0163-2116
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; BACTERIAL DISEASES; DIAGNOSIS; AGE DEPENDENCE; BIOPSY; CARBON 13; CARBON 14 COMPOUNDS; MAN; MATHEMATICAL MODELS; PATIENTS; REGRESSION ANALYSIS; TRACER TECHNIQUES; UREASE; AMIDINASES; ANIMALS; CARBON ISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ENZYMES; EVEN-ODD NUCLEI; HYDROLASES; INFECTIOUS DISEASES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATHEMATICS; NON-PEPTIDE C-N HYDROLASES; NUCLEI; PRIMATES; STABLE ISOTOPES; STATISTICS; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
Citation Formats
Ormand, J E, Talley, N J, Carpenter, H A, Shorter, R G, Conley, C R, Wilson, W R, DiMagno, E P, Zinsmeister, A R, and Phillips, S F. ( sup 14 C)urea breath test for diagnosis of Helicobacter pylori. United States: N. p., 1990.
Web. doi:10.1007/BF01536802.
Ormand, J E, Talley, N J, Carpenter, H A, Shorter, R G, Conley, C R, Wilson, W R, DiMagno, E P, Zinsmeister, A R, & Phillips, S F. ( sup 14 C)urea breath test for diagnosis of Helicobacter pylori. United States. https://doi.org/10.1007/BF01536802
Ormand, J E, Talley, N J, Carpenter, H A, Shorter, R G, Conley, C R, Wilson, W R, DiMagno, E P, Zinsmeister, A R, and Phillips, S F. 1990.
"( sup 14 C)urea breath test for diagnosis of Helicobacter pylori". United States. https://doi.org/10.1007/BF01536802.
@article{osti_6648487,
title = {( sup 14 C)urea breath test for diagnosis of Helicobacter pylori},
author = {Ormand, J E and Talley, N J and Carpenter, H A and Shorter, R G and Conley, C R and Wilson, W R and DiMagno, E P and Zinsmeister, A R and Phillips, S F},
abstractNote = {H. pylori is a potent urease producer, a characteristic that has been exploited in the development of the (14C)- and (13C)urea breath tests. The prevalence of H. pylori infection also is known to increase with advancing age; however, the individual patient's age has not routinely been considered when interpreting urea breath test results. The aim of this study was to validate a short, age-adjusted (14C)urea breath test for use in diagnosing H. pylori infections. Forty-one subjects (28 volunteers, 13 patients) underwent esophagogastroduodenoscopy with biopsies. Subjects were defined as being H. pylori-positive if histology or culture was positive. In addition, all subjects completed a 120-min (14C)urea breath test. A logistic regression analysis adjusting for age was used to estimate the probability of H. pylori positivity as a function of the 14C values generated. Sixteen subjects were H. pylori-positive, and 25 were H. pylori-negative. The 14C values generated between 15 and 80 min were found to be equally predictive in identifying H. pylori-positive subjects. Advancing age was associated with a higher probability of H. pylori-positivity. By taking advantage of the statistical probabilities, older patients could be accurately diagnosed with H. pylori at lower 14C values. We found that (14C)urea breath test to be both a sensitive and specific test that can be abbreviated to a 30-min examination (total test time). Moreover, our mathematical model indicates that a patient's age should be considered in order to optimize interpretation of the (14C)urea breath test, although further observations are needed to confirm this model.},
doi = {10.1007/BF01536802},
url = {https://www.osti.gov/biblio/6648487},
journal = {Digestive Diseases and Sciences; (USA)},
issn = {0163-2116},
number = ,
volume = 35:7,
place = {United States},
year = {Sun Jul 01 00:00:00 EDT 1990},
month = {Sun Jul 01 00:00:00 EDT 1990}
}