The therapeutic efficacy of oral cholecystographic agent (iopanoic acid) in the management of hyperthyroidism

Journal Article · Sun Jul 01 00:00:00 EDT 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6645492

Bal, C; Nair, N ^[1]

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1. Tata Memorial Centre Annexe, Parel, Bombay (India)

Five randomly chosen patients with thyrotoxicosis were administered 1 gm of the oral cholecystographic agent iopanoic acid daily for 21 days. There was a marked fall in T3 levels by 75% of the pretherapy value by 96 hr; values remained normal over the 21-day period. T4 values fell significantly by seven days of therapy, and the decreased values were sustained. FT3 and FT4I also showed corresponding decreases in value. All subjects showed clinical improvement by both subjective and objective criteria. During therapy, escape from the effect of iopanoic acid was not encountered. However, after stopping the drug for 2-4 wk, the patients' iodine-131 uptake become as high as the pretherapy level, enabling them to undergo radioiodine treatment for thyrotoxicosis. The treatment strategy can be aimed at achieving quick euthyroidism and in planning radioiodine treatment as early as possible in high risk patients. This treatment may also be useful in preoperative control of thyrotoxicosis.

• OSTI ID: 6645492
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 31:7; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CONTRAST MEDIA
BIOLOGICAL EFFECTS
HYPERTHYROIDISM
COMBINED THERAPY
IODINE 131
MAN
ORAL ADMINISTRATION
PATIENTS
THYROXINE
TRIIODOTHYRONINE
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE DISEASES
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
PEPTIDE HORMONES
PRIMATES
RADIOISOTOPES
THERAPY
THYROID HORMONES
VERTEBRATES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
550600 - Medicine