Interaction of free fatty acids with the erythrocyte membrane as affected by hyperthermia and ionizing radiation
- K. Marcinkowski Academy of Medicine, Poznan (Poland)
The interference of hyperthermia and ionizing radiation, respectively, with the effects of capric (10:0), lauric (12:0), myristic (14:0), oleic (cis-18:1) and elaidic (trans-18:1) acids on the osmotic resistance of human erythrocytes was investigated. The results are summarized as follows: (A) not only at 37 degrees, but also at 42 and 47{degrees}C lauric acid (12:0) represents the minimum chain length for the biphasic behaviour of protecting against hypotonic hemolysis at a certain lower concentration range and hemolysis promotion at subsequent higher concentrations; (B) with increasing temperatures the protecting as well as the hemolytic effects occur at lower concentrations of the fatty acids; (C) the increase of temperature promotes the extent of hemolysis and reduces the extent of protection against hypotonic hemolysis; (D) Gamma-irradiation of erythrocytes selectively affects the concentration of oleic acid at which maximum protection against hypotonic hemolysis occurs, without altering the minimum concentration for 100% hemolysis.
- OSTI ID:
- 6645095
- Journal Information:
- Bioscience Reports; (USA), Vol. 10:2; ISSN 0144-8463
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARBOXYLIC ACIDS
BIOLOGICAL FUNCTIONS
ERYTHROCYTES
BIOLOGICAL RADIATION EFFECTS
HYPERTHERMIA
BIOLOGICAL EFFECTS
CELL MEMBRANES
GAMMA RADIATION
HEMOLYSIS
MAN
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BODY TEMPERATURE
CELL CONSTITUENTS
ELECTROMAGNETIC RADIATION
FUNCTIONS
IONIZING RADIATIONS
LYSIS
MAMMALS
MATERIALS
MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PRIMATES
RADIATION EFFECTS
RADIATIONS
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture