Cellular regulation of basal and FSH-stimulated cyclic AMP production in irradiated rat testes

Journal Article · Tue May 01 00:00:00 EDT 1990 · Anatomical Record; (USA)

DOI:https://doi.org/10.1002/ar.1092270105· OSTI ID:6644505

Kangasniemi, M; Kaipia, A; Toppari, J; Mali, P; Huhtaniemi, I; Parvinen, M ^[1]

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1. Univ. of Turku (Finland)

Basal and follicle-stimulating hormone (FSH)-stimulated cyclic AMP (cAMP) productions by seminiferous tubular segments from irradiated adult rats were investigated at defined stages of the epithelial cycle when specific spermatogenic cells were low in number. Seven days post-irradiation, depletion of spermatogonia did not influence the basal cAMP production, but FSH response increased in stages II-VIII. Seventeen days post-irradiation when spermatocytes were low in number, there was a small increase in basal cAMP level in stages VII-VIII and FSH-stimulated cAMP production increased in stages VII-XII and XIII-I. At 38 days when pachytene spermatocytes and round spermatids (steps 1-6) were low in number, a decreased basal cAMP production was measured in stages II-VI and IX-XII. FSH-stimulated cAMP output increased in stages VII-XII but decreased in stages II-VI. At 52 days when all spermatids were low in number, basal cAMP levels decreased in all stages of the cycle, whereas FSH response was elevated only in stages VII-XII. All spermatogenic cell types seem to have an effect on cAMP production by the seminiferous tubule in a stage-specific fashion. Germ cells appear to regulate Sertoli cell FSH response in a paracrine way, and a part of cAMP may originate from spermatids stimulated by an unknown FSH-dependent Sertoli cell factor. The FSH-dependent functions may control such phenomena as spermatogonial proliferation, final maturation of spermatids, and onset of meiosis.

• OSTI ID: 6644505
• Journal Information: Anatomical Record; (USA), Vol. 227:1; ISSN 0003-276X
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMP
BIOSYNTHESIS
FSH
BIOCHEMICAL REACTION KINETICS
TESTES
BIOLOGICAL RADIATION EFFECTS
EPITHELIUM
RATS
SPERMATOGENESIS
SPERMATOZOA
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
GAMETES
GAMETOGENESIS
GERM CELLS
GONADOTROPINS
GONADS
HORMONES
KINETICS
MALE GENITALS
MAMMALS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
REACTION KINETICS
RODENTS
SYNTHESIS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals