Recent Pacific Northwest Laboratory beagle and rodent studies

Conference · Sun Jul 01 00:00:00 EDT 1990

OSTI ID:6644171

Gilbert, E S; Park, J F; Cross, F C; Dagle, G E

Analyses based on data from two experimental studies conducted at Pacific Northwest Laboratory will be presented. The first is a lifespan study of beagle dogs exposed to inhaled plutonium. The objectives of this study are, first, to determine the biological effects in dogs of inhaled plutonium at various dose levels, and, second, to obtain dose-effect relationship data that can be used to estimate the risk of these effects in humans. In this study, eighteen-month-old beagle dogs were exposed through inhalation to six different levels and three different types of plutonium. The lowest level corresponds to the maximum permissible level for a plutonium worker, while the highest level is a level at which radiation pneumonitis is likely to cause early death. {sup 239}PuO{sub 2} was chosen because it is the form of plutonium to which people working in nuclear fuel processing and storage industries are likely to be exposed. {sup 238}PuO{sub 2} and {sup 239}Pu(NO{sub 3}){sub 4} were chosen because they result in different spatial and temporal distribution of radiation dose, and thus can provide information on the influence of these factors on risk. The second experiment is a lifespan study of rodents exposed through inhalation to radon and radon progeny. For the rodent experiments to be considered in this presentation, exposures were initiated at about 90 days of age at rates of 5, 50, and 500 WLM per week. Cumulative exposure levels were 320, 640, 1280, 2560, and 5120 WLM for animals exposed at 50 and 500 WLM per week, and 320 WLM for animals exposed at 5 WLM per week. 7 refs.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: DOE/NE
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6644171
• Report Number(s): PNL-SA-18380; CONF-9007165-1; ON: DE90017140
• Resource Relation: Conference: American statistical association (ASA) conference on radiation and health, Copper Mountain, CO (USA), 8-13 Jul 1990
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BEAGLES
LIFE SPAN
DAUGHTER PRODUCTS
INHALATION
PLUTONIUM 238
BIOLOGICAL EFFECTS
PLUTONIUM 239
PLUTONIUM DIOXIDE
PLUTONIUM NITRATES
RADON
BATTELLE PACIFIC NORTHWEST LABORATORIES
DOSE COMMITMENTS
LUNGS
NEOPLASMS
RADIONUCLIDE KINETICS
RISK ASSESSMENT
RODENTS
SPATIAL DOSE DISTRIBUTIONS
TEMPORAL DOSE DISTRIBUTIONS
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BODY
CHALCOGENIDES
DISEASES
DOGS
ELEMENTS
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FLUIDS
GASES
HEAVY ION DECAY RADIOISOTOPES
HEAVY NUCLEI
INTAKE
ISOTOPES
MAMMALS
NATIONAL ORGANIZATIONS
NITRATES
NITROGEN COMPOUNDS
NONMETALS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
RADIATION DOSE DISTRIBUTIONS
RADIOISOTOPES
RARE GASES
RESPIRATORY SYSTEM
SILICON 32 DECAY RADIOISOTOPES
TRANSURANIUM COMPOUNDS
US DOE
US ERDA
US ORGANIZATIONS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells