Mn-54 DTPA distribution in dogs: Evaluation as a potential NMR contrast agent
Several paramagnetic ions are currently being evaluated as potential contrast agents for NMR imaging. To date the most successful of these appears to be Gd-DTPA. The authors recently undertook an investigation into the kinetics of biodistribution of Mn-DTPA to determine if this agent showed any tissue specific uptake, and if so, to optimize the time for imaging. In order to obviate the need for repetitive quantitative NMR imaging they have substituted tracer amounts of Mn-54 for the stable ion. Following intravenous injection into three mongrel dogs, samples of blood, bowel, liver, and pancreas were obtained at 3, 15, 30 and 60 minutes and 2, 4 and 6 hours post-injection. Radioactivity, and thus tissue concentration, was then determined in a gamma counter. Urine was also collected throughout the study. At six hours 58.4 +- 7.1% of the injected dose had been excreted in the urine. Peak liver accumulation occurred within 30 minutes (0.503 +- 0.144% injected dose/gm x kg body weight). The pancreas also showed a relatively high accumulation of tracer (0.247 +- 0.039%/gram x kg body weight) by four hours. The pancreas to liver ratios were highest at six hours (.73). The blood concentration fell very rapidly with little tracer remaining in the blood at one hour. The results of these experiments indicate that a significant portion of the injected material was concentrated by liver and pancreas. Unlike MnCl/sub 2/, most of the Mn-DTPA is excreted in the urine. This excretion is expected to reduce the toxicity of the injected material. These results are being used to establish the optimal protocols for NMR imaging with Mn-DTPA.
- Research Organization:
- Univ. of Minnesota Hospitals, Minneapolis, MN
- OSTI ID:
- 6644100
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD
NUCLEAR MAGNETIC RESONANCE
CONTRAST MEDIA
TISSUE DISTRIBUTION
DTPA
EXCRETION
LABELLING
UPTAKE
GASTROINTESTINAL TRACT
LIVER
MANGANESE 54
DIAGNOSTIC USES
PANCREAS
BIOLOGICAL ACCUMULATION
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOGS
GADOLINIUM ISOTOPES
IMAGE PROCESSING
IMAGES
INJECTION
MANGANESE COMPLEXES
QUANTITY RATIO
TOXICITY
URINE
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COMPLEXES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAGNETIC RESONANCE
MAMMALS
MANGANESE ISOTOPES
MATERIALS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROCESSING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RARE EARTH ISOTOPES
RESONANCE
TRANSITION ELEMENT COMPLEXES
USES
VERTEBRATES
WASTES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550602 - Medicine- External Radiation in Diagnostics- (1980-)