Place of radiotherapy in the treatment of synovial sarcoma
This paper reviews 36 patients with synovial sarcoma; 18 were referred within three months of surgery. None had undergone en bloc excision and all were treated with post-operative radiotherapy. Local control and survival were analyzed with respect to Tumor Node Metastasis Classification, histology, site of primary and surgical procedure. Eight patients with T1-2N0M0 tumors were alive and well (minimum two year follow-up) following excision and radiotherapy; 7 had a normally functional extremity. In contrast, only one of 8 patients with T3N0M0 tumors is alive and well. Seven of 8 patients with well or moderately differentiated histology were alive and well whereas no patient with poorly differentiated histologies survived. Six of 7 patients were alive and well if their tumor was distal to the elbow or knee whereas none of those who had a primary thigh synovial sarcoma survived. Eighteen patients were referred with recurrent disease and 2 were salvaged. A management policy is proposed for synovial sarcoma with the integrated use of surgery, radiation and chemotherapy; it emphasizes optimal cure rates and a functional extremity reserving amputation for salvage.
- Research Organization:
- Princess Margaret Hospital, Toronto, Ontario
- OSTI ID:
- 6643404
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7:1
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE JOINTS
BIOLOGICAL RADIATION EFFECTS
SARCOMAS
TUMOR CELLS
RADIOSENSITIVITY
BIOLOGICAL LOCALIZATION
CHEMOTHERAPY
EXTERNAL IRRADIATION
HISTOLOGICAL TECHNIQUES
PATIENTS
RADIATION DOSES
RADIOTHERAPY
SURGERY
SURVIVAL CURVES
ANIMAL CELLS
BIOLOGICAL EFFECTS
BODY
DISEASES
DOSES
IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
SKELETON
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man