Use of total lymphoid irradiation (TLI) as immunosuppressive therapy for organ allotransplantation and autoimmune diseases
Radiation induced alterations in the number and immune functions of peripheral blood lymphocytes have recently been described in patients treated with fractionated localized or extended field radiotherapy for carcinoma of the breast, lung, bladder uterine cervix, prostate, testicular tumors, head and neck tumors, Hodgkin's disease, and in children receiving prophylactic craniospinal radiation for acute lymphoblast leukemia. Most studies have demonstrated an acture peripheral blood lymphocytopenia and varying degrees of suppression of immune functions such as the in vitro blastogenic responses to stimulation with lectins or with allogeneic lymphocytes in the mixed lymphocyte reaction (MLR), and in the in vivo delayed hypersensitivity responses to dinitrochlorobenzene (DNCB) and intradermally injected bacterial and fungal antigens. Most studies have also shown various degrees of recovery of the above immune functions within the first few years after completion of treatment.
- Research Organization:
- Hebrew Univ., Jerusalem, Israel
- OSTI ID:
- 6643394
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7:1
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IMMUNOSUPPRESSION
RADIOINDUCTION
LYMPHOCYTES
BIOLOGICAL RADIATION EFFECTS
NEOPLASMS
RADIOSENSITIVITY
BLADDER
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
HEAD
HODGKINS DISEASE
IN VITRO
LEUKEMIA
LUNGS
MAMMARY GLANDS
PATIENTS
PROSTATE
RADIOTHERAPY
SURVIVAL CURVES
TESTES
UTERUS
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
FEMALE GENITALS
GLANDS
GONADS
HEMIC DISEASES
IRRADIATION
LEUKOCYTES
LYMPHOMAS
MALE GENITALS
MATERIALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
RESPIRATORY SYSTEM
SOMATIC CELLS
THERAPY
URINARY TRACT
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man