Effects of polychlorinated biphenyls and lipemia on serum analytes

Journal Article · Wed Jan 01 00:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530935· OSTI ID:6641308

Steinberg, K K; Freni-Titulaer, L W.J.; Rogers, T N; Burse, V W; Mueller, P W; Stehr, P A; Miller, D T; Steele, G

Twelve serum analytes (triglycerides, cholesterol, total and conjugated bilirubin, high-density-lipoprotein cholesterol (HDL-C) alkaline phosphatase (AP), gammaglutamyl transferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), ..beta..-glucoronidase (..beta..-glu), alanine aminopeptidase (AAP), and 5'-nucleotidase (5'nuc)) were measured to investigate their correlation with exposure to polychlorinated biphenyls (PCBs) and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). The relationship between serum lipids, lipophilic toxicants, and the analytes was also evaluated. The ..beta..-glue, 5'nuc, triglycerides, cholesterol, and total bilirubin correlated positively and significantly with log concentrations of serum total PCBs and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), a metabolite of DDT. The more highly chlorinated PCBs had significant, positive correlations with several serum analytes, but the less chlorinated PCBs correlated significantly and negatively only with HDL-cholesterol. Triglyercide- and cholesterol-rich lipoproteins were added to serum to determine the effects of lipids on these assays. Several were spuriously elevated. AP and ..beta..-glu were not affected by lipoprotein addition with the methods used in this study. AAP was increased significantly only at triglyceide concentrations exceeding 400 mg/dl.

• Research Organization: Centers for Disease Control, Atlanta, GA
• OSTI ID: 6641308
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 19:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHLORINATED AROMATIC HYDROCARBONS
HEALTH HAZARDS
DDT
CHOLESTEROL
LIPIDS
METABOLITES
TRANSFERASES
TRIGLYCERIDES
AROMATICS
ENZYMES
ESTERS
HALOGENATED AROMATIC HYDROCARBONS
HAZARDS
HYDROXY COMPOUNDS
INSECTICIDES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PESTICIDES
STEROIDS
STEROLS
560300* - Chemicals Metabolism & Toxicology