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Title: Hematological effects of unilateral and bilateral exposures of dogs to 300-kVp X rays

Abstract

Accidental exposures to ionizing radiation from external sources usually result in an inhomogeneous dose distribution rather than a homogeneous total-body irradiation (TBI). To study the hematological effects of an inhomogeneous dose distribution, dogs were unilaterally exposed to a beam of 300 kVp X rays (HVL = 3.8 mm Cu) with their left side directed to the source. The entrance and exit surface doses were 3.8 Gy and 0.9 Gy, respectively. Dose measurements performed in bone marrow spaces of various bones revealed a maximum of 3.1 Gy in the head of the left humerus and a minimum of 0.9 Gy in the right iliac crest. Based on survival for granulocyte-macrophage progenitor cells (GM-CFC) determined in different bone marrow sites 24 h after the exposure, the dose-dependent reduction ranged from 0.44 to 16% of the control values. The regeneration of the GM-CFC compartments in the various bone marrow spaces showed patterns which were independent of each other up to Day 28. Values were normal again at Day 125 after exposure. For comparative purposes, three dogs were exposed bilaterally to achieve a homogeneous dose distribution. They received a TBI of 2.4 Gy, which according to previous calculations should have caused the same systemicmore » damage to the GM-CFC compartment as the unilateral exposure. The peripheral blood cell changes, including the GM-CFC, and the colony stimulating activity in the serum showed a similar pattern for both exposures. These findings support the hypothesis that the overall survival fraction of progenitor cells in the bone marrow is the main determinant of the blood cell changes, independent of the anatomical distribution.« less

Authors:
;  [1]
  1. Univ. of Ulm (Germany, F.R.)
Publication Date:
OSTI Identifier:
6639744
Resource Type:
Journal Article
Journal Name:
Radiation Research; (USA)
Additional Journal Information:
Journal Volume: 123:1; Journal ID: ISSN 0033-7587
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW; BIOLOGICAL RADIATION EFFECTS; DOGS; DOSE-RESPONSE RELATIONSHIPS; LEUKOCYTES; MACROPHAGES; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; STEM CELLS; SURVIVAL TIME; X RADIATION; ANIMAL CELLS; ANIMAL TISSUES; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DOSES; ELECTROMAGNETIC RADIATION; HEMATOPOIETIC SYSTEM; IONIZING RADIATIONS; MAMMALS; MATERIALS; ORGANS; PHAGOCYTES; RADIATION EFFECTS; RADIATIONS; SOMATIC CELLS; TISSUES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Baltschukat, K, and Nothdurft, W. Hematological effects of unilateral and bilateral exposures of dogs to 300-kVp X rays. United States: N. p., 1990. Web. doi:10.2307/3577651.
Baltschukat, K, & Nothdurft, W. Hematological effects of unilateral and bilateral exposures of dogs to 300-kVp X rays. United States. https://doi.org/10.2307/3577651
Baltschukat, K, and Nothdurft, W. 1990. "Hematological effects of unilateral and bilateral exposures of dogs to 300-kVp X rays". United States. https://doi.org/10.2307/3577651.
@article{osti_6639744,
title = {Hematological effects of unilateral and bilateral exposures of dogs to 300-kVp X rays},
author = {Baltschukat, K and Nothdurft, W},
abstractNote = {Accidental exposures to ionizing radiation from external sources usually result in an inhomogeneous dose distribution rather than a homogeneous total-body irradiation (TBI). To study the hematological effects of an inhomogeneous dose distribution, dogs were unilaterally exposed to a beam of 300 kVp X rays (HVL = 3.8 mm Cu) with their left side directed to the source. The entrance and exit surface doses were 3.8 Gy and 0.9 Gy, respectively. Dose measurements performed in bone marrow spaces of various bones revealed a maximum of 3.1 Gy in the head of the left humerus and a minimum of 0.9 Gy in the right iliac crest. Based on survival for granulocyte-macrophage progenitor cells (GM-CFC) determined in different bone marrow sites 24 h after the exposure, the dose-dependent reduction ranged from 0.44 to 16% of the control values. The regeneration of the GM-CFC compartments in the various bone marrow spaces showed patterns which were independent of each other up to Day 28. Values were normal again at Day 125 after exposure. For comparative purposes, three dogs were exposed bilaterally to achieve a homogeneous dose distribution. They received a TBI of 2.4 Gy, which according to previous calculations should have caused the same systemic damage to the GM-CFC compartment as the unilateral exposure. The peripheral blood cell changes, including the GM-CFC, and the colony stimulating activity in the serum showed a similar pattern for both exposures. These findings support the hypothesis that the overall survival fraction of progenitor cells in the bone marrow is the main determinant of the blood cell changes, independent of the anatomical distribution.},
doi = {10.2307/3577651},
url = {https://www.osti.gov/biblio/6639744}, journal = {Radiation Research; (USA)},
issn = {0033-7587},
number = ,
volume = 123:1,
place = {United States},
year = {Sun Jul 01 00:00:00 EDT 1990},
month = {Sun Jul 01 00:00:00 EDT 1990}
}