Canine as a biomedical research model: immunological, hematological, and oncological aspects

Technical Report · Tue Jan 01 00:00:00 EST 1980

DOI:https://doi.org/10.2172/6637778· OSTI ID:6637778

Shifrine, M.; Wilson, F. D. ^[1]

---

1. eds.

The canine has been used as a biomedical research model in radiation studies by a number of laboratories supported primarily by the US Department of Energy and its predecessors. These studies were unique in that they covered the life spans of the canines and permitted the collection of data from birth to death under controlled conditions. Since these were multiparametric studies, an extensive data base has been established, not the least of which are normative values covering all biologic systems, including immunohematology. The canine model has also been extensively used by other groups, such as transplantation biologists. The virtues of the canine as a model in these and many other endeavors are becoming increasingly more apparent with the passing of time. One of the primary goals of this volume was to compile the knowledge and experience of researchers using the canine model and to focus their expertise on furthering the use of the canine for studies in immunology, hematology, and oncology. We have attempted to present some of the contemporary, diverse uses of the canine in biomedical research, emphasizing immunologic endpoints, and also to present in detail some of the latest technology used in such studies.

• Research Organization: California Univ., Davis (USA). Lab. for Energy-Related Health Research
• DOE Contract Number: EY-76-C-03-0472
• OSTI ID: 6637778
• Report Number(s): DOE/TIC-10191; TRN: 81-005018
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
BEAGLES
BIOLOGICAL MODELS
RESEARCH PROGRAMS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BONE MARROW
CELL KILLING
IMMUNOLOGY
KIDNEYS
METASTASES
NEOPLASMS
RADIOBIOLOGY
REVIEWS
TRANSPLANTS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGY
BODY
DISEASES
DOCUMENT TYPES
DOGS
HEMATOPOIETIC SYSTEM
MAMMALS
ORGANS
RADIATION EFFECTS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550900 - Pathology