Cutaneous mast cell maturation does not depend on an intact bone marrow microenvironment
A study was made to determine whether the maturation of murine cutaneous mast cells from stem cells depends on an intact bone marrow microenvironment. Normal bone marrow cells (+/+) were infused into 2 groups of mast cell-deficient mice: WBB6F1-W/Wv mice and /sup 89/Sr-pretreated W/Wv mice. /sup 89/Sr is a long-lived bone-seeking radioisotope which provides continuous irradiation of the marrow and thereby ablates the marrow microenvironment. Skin biopsies revealed that the /sup 89/Sr-pretreated mice and the controls had repopulated their skin with mast cells equally well. Natural killer cell function was significantly depressed in the /sup 89/Sr-treated mice, confirming that the marrow microenvironment had been functionally altered. It appears that, although the precursors for cutaneous mast cells are marrow derived, they do not need an intact marrow microenvironment for maturation.
- Research Organization:
- Univ. of Texas Health Science Center, Dallas
- OSTI ID:
- 6628610
- Journal Information:
- J. Invest. Dermatol.; (United States), Vol. 82:1
- Country of Publication:
- United States
- Language:
- English
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BONE MARROW
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STEM CELLS
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ALKALINE EARTH ISOTOPES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
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INTERMEDIATE MASS NUCLEI
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MAMMALS
NUCLEI
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RODENTS
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