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Title: Differences in the distribution of iodine and iodide in the Sprague-Dawley rat

Abstract

Use of iodine as a drinking water disinfectant for extended space flight raises concerns about potential chronic effects on health. A key question is whether the chemical form of iodine might play a role. To address this question the influence chemical form has on the uptake and distribution of radioiodine was studied in fed and fasted rats. Following oral administration of 125I2 or 125I-, blood 125I levels were maximal at 2 hr and reached similar concentrations in fed animals receiving 125I- and fasted animals receiving either 125I2 or 125I-. However, when 125I2 was administered to fed animals the initial levels of 125I into blood were significantly lower than after the other treatments. The half-life of elimination of 125I from the blood appeared independent of the form of iodine administered. The initial distribution of 125I to the thyroid depended sharply on chemical form, being greater when iodide rather than iodine was administered, whether animals were fed or fasted. In fed animals administered I2, this may largely be explained by the increased retention of 125I in the stomach contents. In fasted animals, both stomach content and blood levels of 125I were similar whether I2 or I- was administered. Since thyroid uptake ofmore » iodine is specific for I-, this suggests that the form of iodine in the blood was different in animals administered I2. This notion was further supported by the finding that pretreatment of animals with varying concentrations of I- in drinking water was four times as effective in suppressing the uptake of a test dose of 125I- than pretreatment with equivalent concentrations of I2.« less

Authors:
;  [1]
  1. Washington State Univ., Pullman (USA)
Publication Date:
OSTI Identifier:
6621416
Resource Type:
Journal Article
Journal Name:
Fundamental and Applied Toxicology; (USA)
Additional Journal Information:
Journal Volume: 15:1; Journal ID: ISSN 0272-0590
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; IODIDES; METABOLISM; IODINE; BIOLOGICAL HALF-LIFE; COMPARATIVE EVALUATIONS; DRINKING WATER; FASTING; FECES; INTESTINAL ABSORPTION; IODINE 125; ORAL ADMINISTRATION; RATS; THYROID; TISSUE DISTRIBUTION; TRACER TECHNIQUES; ABSORPTION; ANIMALS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; ENDOCRINE GLANDS; GLANDS; HALIDES; HALOGEN COMPOUNDS; HALOGENS; HYDROGEN COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE COMPOUNDS; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MATERIALS; NONMETALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; OXYGEN COMPOUNDS; RADIOISOTOPES; RODENTS; UPTAKE; VERTEBRATES; WASTES; WATER; 550501* - Metabolism- Tracer Techniques

Citation Formats

Thrall, K D, and Bull, R J. Differences in the distribution of iodine and iodide in the Sprague-Dawley rat. United States: N. p., 1990. Web. doi:10.1016/0272-0590(90)90164-F.
Thrall, K D, & Bull, R J. Differences in the distribution of iodine and iodide in the Sprague-Dawley rat. United States. https://doi.org/10.1016/0272-0590(90)90164-F
Thrall, K D, and Bull, R J. 1990. "Differences in the distribution of iodine and iodide in the Sprague-Dawley rat". United States. https://doi.org/10.1016/0272-0590(90)90164-F.
@article{osti_6621416,
title = {Differences in the distribution of iodine and iodide in the Sprague-Dawley rat},
author = {Thrall, K D and Bull, R J},
abstractNote = {Use of iodine as a drinking water disinfectant for extended space flight raises concerns about potential chronic effects on health. A key question is whether the chemical form of iodine might play a role. To address this question the influence chemical form has on the uptake and distribution of radioiodine was studied in fed and fasted rats. Following oral administration of 125I2 or 125I-, blood 125I levels were maximal at 2 hr and reached similar concentrations in fed animals receiving 125I- and fasted animals receiving either 125I2 or 125I-. However, when 125I2 was administered to fed animals the initial levels of 125I into blood were significantly lower than after the other treatments. The half-life of elimination of 125I from the blood appeared independent of the form of iodine administered. The initial distribution of 125I to the thyroid depended sharply on chemical form, being greater when iodide rather than iodine was administered, whether animals were fed or fasted. In fed animals administered I2, this may largely be explained by the increased retention of 125I in the stomach contents. In fasted animals, both stomach content and blood levels of 125I were similar whether I2 or I- was administered. Since thyroid uptake of iodine is specific for I-, this suggests that the form of iodine in the blood was different in animals administered I2. This notion was further supported by the finding that pretreatment of animals with varying concentrations of I- in drinking water was four times as effective in suppressing the uptake of a test dose of 125I- than pretreatment with equivalent concentrations of I2.},
doi = {10.1016/0272-0590(90)90164-F},
url = {https://www.osti.gov/biblio/6621416}, journal = {Fundamental and Applied Toxicology; (USA)},
issn = {0272-0590},
number = ,
volume = 15:1,
place = {United States},
year = {Sun Jul 01 00:00:00 EDT 1990},
month = {Sun Jul 01 00:00:00 EDT 1990}
}