Nonspecific inhibition of alloantigen-induced proliferation by bone marrow natural regulatory cells

Conference · Sun Mar 01 00:00:00 EST 1981 · Transplant. Soc., Int. Cong., Proc.; (United States)

OSTI ID:6620124

Dorshkind, K; Rosse, C

We have previously reported that a lymphocyte-enriched fraction ofmurine bone marrow (BML) contains natural regulatory cells (NRC) that can inhibit in vitro proliferative and cytotoxic responses to alloantigens on a dose-dependent basis. In view of the potential importance of these cells to the outcome of bone marrow transplantation, we have undertaken a series of studies designed to inestigate the properties of the effector cell(s). Since clinical and experimental bone marrow transplantation is often performed by inoculating histoincompatible marrow into irradiated hosts, we have investigated the effects of irradiation on NRC and their ability to function across major and minor histocompatibility barriers. In this brief communication, we report that NRC can nonspecifically inhibit cellular immune responses across histocompatibility barriers and are not affected by high doses of irraddiation. In addition, we report that NRC are not T or B lymphocytes.

• Research Organization: Univ. of Washington, Seattle
• DOE Contract Number: EY-76-06-2225
• OSTI ID: 6620124
• Journal Information: Transplant. Soc., Int. Cong., Proc.; (United States), Vol. 13:1; Conference: 8. international congress of the Transplantation Society, Boston, MA, USA, 29 Jun 1980
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
BONE MARROW CELLS
BIOLOGICAL RADIATION EFFECTS
EVALUATION
CELL PROLIFERATION
INHIBITION
IMMUNITY
ANTIGENS
GAMMA RADIATION
GRAFT-HOST REACTION
IMMUNOGLOBULINS
LYMPHOCYTES
MICE
SPLEEN CELLS
TRANSPLANTS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GLOBULINS
IONIZING RADIATIONS
LEUKOCYTES
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)
550301 - Cytology- Tracer Techniques