Constitutional Ip36 deletion in a child with neuroblastoma
- Children's Hospital, Philadelphia, PA (United States) Univ. of Pennsylvania, Philadelphia (United States)
- Washington Univ., St. Louis, MO (United States)
The authors describe a child with dysmorphic features, as well as developmental and growth delay, who developed neuroblastoma at 5 mo of age. Cytogenetic analysis of blood lymphocytes revealed an interstitial deletion of 1p36.1 [r arrow] 1p36.2, which was apparent only with high-resolution banding. Molecular analysis with a collection of polymorphic DNA probes for 1p confirmed an interstitial deletion involving subbands of 1p36. Deletions of this region are a common finding in neuroblastoma cells from patients with advanced stages of disease. Therefore, these results (a) suggest that constitutional deletion of this region predisposed the patient to the development of neuroblastoma and (b) support the localization of a neuroblastoma tumor-suppressor locus to 1p36. 48 refs., 2 figs.
- OSTI ID:
- 6615985
- Journal Information:
- American Journal of Human Genetics; (United States), Vol. 52:1; ISSN 0002-9297
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HUMAN CHROMOSOMES
MAPPING
NERVOUS SYSTEM
SARCOMAS
BANDING TECHNIQUES
CYTOLOGICAL TECHNIQUES
DNA
DNA HYBRIDIZATION
GROWTH
LYMPHOCYTES
PROBES
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMES
CONNECTIVE TISSUE CELLS
DISEASES
HYBRIDIZATION
LEUKOCYTES
MATERIALS
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
SOMATIC CELLS
550400* - Genetics