Does nitrogen dioxide exposure increase airways responsiveness
A number of reports have suggested that exposure to nitrogen dioxide (NO2) may cause increased airways responsiveness (AR). Twenty studies of asthmatics and five studies of healthy subjects exposed to NO[sub 2] were used to test the hypothesis using a simple method of meta-analysis. Individual data were obtained for the above studies and the direction of change in AR was determined for each subject. Only studies with available individual data were used. Subjects from these studies whose directional change in AR could not be determined were excluded. The fraction of positive responses (i.e. increased AR) was determined for all subjects within a group and tested for significance using a sign test. Data were also grouped according to NO[sub 2] concentration and by whether the exposure included exercise.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
- OSTI ID:
- 6615897
- Report Number(s):
- PB-93-156271/XAB; EPA-600/J-93/023
- Resource Relation:
- Other Information: Pub. in Toxicology and Industrial Health, Vol. 8, No. 5, 273-283(Oct 1992)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
NITROGEN DIOXIDE
BIOCHEMISTRY
AIR POLLUTION
ENVIRONMENTAL EXPOSURE
EXERCISE
HYPOTHESIS
LUNGS
PUBLIC HEALTH
RESPIRATION
REVIEWS
BODY
CHALCOGENIDES
CHEMISTRY
DOCUMENT TYPES
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RESPIRATORY SYSTEM
560300* - Chemicals Metabolism & Toxicology
570000 - Health & Safety