Efficacy of astatine-211-labeled monoclonal antibody in treatment of murine T-cell lymphoma

Journal Article · Thu Jan 01 00:00:00 EST 1987 · NCI Monogr.; (United States)

OSTI ID:6614250

Harrison, A; Royle, L

The short-lived isotope /sup 211/At (half-life, 7.2 hr), an alpha particle-emitting halogen, has been attached to a monoclonal antibody (anti-thy 1.1, IgG1, OX7) and used in mice in the treatment of a thy 1.1 T-cell lymphoma (A120). Forty-eight hours after receiving an iv injection of 10(3) or 10(5) A120 cells, mice were treated with phosphate-buffered saline, /sup 211/At-, antibody alone, or /sup 211/At conjugated to OX7. Treatment with the /sup 211/At-labeled OX7 conjugate increased the median survival time of mice and probably cured (survival at 200 days) 6 of the 15 mice given 10(5) cells and 21 of the 27 mice given 10(3) cells.

• Research Organization: Medical Research Council Radiobiology Unit, Didcot, England
• OSTI ID: 6614250
• Journal Information: NCI Monogr.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LYMPHOMAS
RADIOIMMUNOTHERAPY
MONOCLONAL ANTIBODIES
LABELLING
THERAPEUTIC USES
ASTATINE 211
BIOLOGICAL HALF-LIFE
LYMPHOCYTES
MICE
SURVIVAL CURVES
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMALS
ANTIBODIES
ASTATINE ISOTOPES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
ISOTOPES
LEUKOCYTES
MAMMALS
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
SOMATIC CELLS
THERAPY
USES
VERTEBRATES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)