Therapeutic application of radiolabeled monoclonal antibody UJ13A in children with disseminated neuroblastoma

Journal Article · Thu Jan 01 00:00:00 EST 1987 · NCI Monogr.; (United States)

OSTI ID:6614228

Lashford, L; Jones, D; Pritchard, J; Gordon, I; Breatnach, F; Kemshead, J T

Dosimetric data from UJ13A scanning studies using /sup 131/I are presented for children with stage IV neuroblastoma and primary brain tumor. The data demonstrate a large variation among patients in dose delivery to vulnerable organs and tumors. Against this background, a phase I toxicity study is under way with escalating amounts of conjugate administered to patients who have stage IV neuroblastoma. Major toxicity has been confined to bone marrow aplasia and necessitates bone marrow harvest prior to therapy. Specific problems encountered include altered kinetics during therapy following tracer studies and adequate dose delivery in large tumor masses.

• Research Organization: Hospital for Sick Children, London, England
• OSTI ID: 6614228
• Journal Information: NCI Monogr.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
NEOPLASMS
MONOCLONAL ANTIBODIES
LABELLING
THERAPEUTIC USES
RADIOIMMUNOTHERAPY
BONE MARROW
CHILDREN
IODINE 131
LIVER
PATIENTS
RADIOTHERAPY
TOXICITY
AGE GROUPS
ANIMAL TISSUES
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
GLANDS
HEMATOPOIETIC SYSTEM
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
THERAPY
TISSUES
USES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)