Cytogenetic surveillance of workers exposed to genotoxic chemicals: Preliminary experiences from a prospective cancer study in a cytogenetic cohort
- Institute of Occupational Health, Helsinki (Finland)
Cytogenetic endpoints, conventionally chromosomal aberrations, and later sister chromatid exchanges and micronuclei have long been used to assess exposure of human populations to genotoxic agents. Although the adverse nature of somatic chromosome damage is recognized at the group level, no ill-health manifestations have been causally related to cytogenetic damage at the individual level. In work-related exposures, e.g., ethylene oxide, styrene, benzene, vinyl chloride, and alkylating anticancer agents have been shown to induce somatic chromosomal damage in several studies. For all of these, a carcinogenic risk to humans has also been documented. The possible association of somatic chromosome damage and cancer will be elucidated in a Nordic prospective study. The objective is to find out the significance of a high or low score in any of the cytogenetic parametres to risk of cancer. In the Finnish part of the cohort of 806 individuals, 10 cases of cancer were observed during the first follow-up period. Although the cohort is young and the numbers small, a slightly significant (P = 0.04) trend was observed for individuals with cancer and a score of chromosomal aberrations. No trend was observed for sister chromatid exchanges. The application of cytogenetic surveillance is still not routine methodology, but it is useful and informative in carefully controlled study designs. Special efforts should be directed toward combining different disciplines, i.e., cytogenetics, adduct monitoring, and end-effect epidemiology, in order to reach quantitativeness in risk assessment.13 references.
- OSTI ID:
- 6614041
- Journal Information:
- Teratogenesis, Carcinogenesis, and Mutagenesis; (USA), Vol. 10:3; ISSN 0270-3211
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BENZENE
GENETIC EFFECTS
ETHYLENE
STYRENE
VINYL CHLORIDE
ANTINEOPLASTIC DRUGS
CHROMOSOMAL ABERRATIONS
MAN
NEOPLASMS
REVIEWS
RISK ASSESSMENT
SISTER CHROMATID EXCHANGES
ALKENES
ALKYLATED AROMATICS
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
CHLORINATED ALIPHATIC HYDROCARBONS
DISEASES
DOCUMENT TYPES
DRUGS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROCARBONS
MAMMALS
MUTATIONS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PRIMATES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology