Exploratory case-control study of brain tumors in adults
An exploratory study of brain tumors in adults was carried out using 215 cases diagnosed in Southern Ontario between 1979 and 1982, with an individually matched, hospital control series. Significantly elevated risks were observed for reported use of spring water, drinking of wine, and consumption of pickled fish, together with a significant protective effect for the regular consumption of any of several types of fruit. While these factors are consistent with a role for N-nitroso compounds in the etiology of these tumors, for several other factors related to this hypothesis, no association was observed. Occupation in the rubber industry was associated with a significant relative risk of 9.0, though no other occupational associations were seen. Two previously unreported associations were with smoking nonfilter cigarettes with a significant trend and with the use of hair dyes or sprays. The data do not support an association between physical head trauma requiring medical attention and risk of brain tumors and indicate that exposure to ionizing radiation and vinyl chloride monomer does not contribute any appreciable fraction of attributable risk in the population studied. The findings warrant further detailed investigation in future epidemiologic studies.
- Research Organization:
- Univ. of Toronto, Ontario
- OSTI ID:
- 6610642
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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BRAIN
NEOPLASMS
ETIOLOGY
RISK ASSESSMENT
ADULTS
AGED ADULTS
DIET
ENVIRONMENTAL EXPOSURE
EPIDEMIOLOGY
HEALTH HAZARDS
INJURIES
NITROSO COMPOUNDS
OCCUPATIONAL DISEASES
ONTARIO
RUBBER INDUSTRY
TOBACCO SMOKES
VINYL CHLORIDE
WATER SUPPLY
X RADIATION
AEROSOLS
AGE GROUPS
BODY
CANADA
CENTRAL NERVOUS SYSTEM
CHLORINATED ALIPHATIC HYDROCARBONS
COLLOIDS
DISEASES
DISPERSIONS
ELECTROMAGNETIC RADIATION
HALOGENATED ALIPHATIC HYDROCARBONS
HAZARDS
INDUSTRY
IONIZING RADIATIONS
NERVOUS SYSTEM
NORTH AMERICA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATIONS
RESIDUES
SMOKES
SOLS
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