Histamine paw edema of mice was increased and became H[sub 2]-antagonist sensitive by co-injection of nitric oxide forming agents, but serotonin paw edema was decreased

Journal Article · Fri Jan 01 00:00:00 EST 1993 · Life Sciences; (United States)

OSTI ID:6610102

Oyanagui, Yoshihiko; Sato, Sachio ^[1]

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1. Fujisawa Pharmaceutical Co., Osaka (Japan)

Nitric oxide (NO) surprisingly caused the opposite effect on histamine and serotonin edema. The local injection of acidified nitrite (0.3-30 [mu]g/paw which correspond 10 [mu]g-1mg/kg) increased histamine edema of mice up to 45[plus minus]4% and suppressed serotonin edema to 90[plus minus]3%. Other NO-generators (nitroprusside sodium and hydroxylamine) showed similar effects. These results were in accordance with previous data on endogenous NO. Methylene blue (MB, 30ng/paw which corresponds to 1 [mu]g/kg) suppressed histamine edema (62[plus minus]3%) and increased serotonin edema (43[plus minus]3%) in normal mice, being reversed by acidified nitrite. This suggests the involvement of guanosine 3[prime], 5[prime]-cyclic monophosphate (cGMP) formation for the action of NO. Histamine edema became sensitive to H[sub 2]-antagonist, cimetidine, by co-injection of 30 [mu]g/paw (which corresponds to 1mg/kg) acidified nitrite (ED[sub 50] = 30 [mu]g/kg versus [much gt] 1mg/kg). NO seemed to modify the histamine receptor(s) or tautomeric form of histamine. NO, O[sup [minus]][sub 2] and other oxyradicals might finely control the vascular permeability together with inflammatory mediators. 20 refs., 4 figs.

• OSTI ID: 6610102
• Journal Information: Life Sciences; (United States), Vol. 52:17; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NITRIC OXIDE
BIOLOGICAL EFFECTS
EDEMA
GUANOSINE
HISTAMINE
HYDROXYLAMINE
INJECTION
METHYLENE BLUE
MICE
PERMEABILITY
SEROTONIN
AMINES
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIMICROBIAL AGENTS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZINES
AZOLES
CHALCOGENIDES
CHLORIDES
CHLORINE COMPOUNDS
DRUGS
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIDAZOLES
INDOLES
INTAKE
MAMMALS
NEUROREGULATORS
NITROGEN COMPOUNDS
NITROGEN OXIDES
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHENOTHIAZINES
PURINES
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RIBOSIDES
RODENTS
SYMPATHOMIMETICS
SYMPTOMS
TRYPTAMINES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology