Phenoxy herbicides and chlorophenols as risk factors for soft tissue sarcoma and non-Hodgkin's lymphoma

Conference · Mon Sep 01 00:00:00 EDT 1986 · Am. J. Epidemiol.; (United States)

OSTI ID:6608883

Woods, J; Polissar, L; Severson, R; Heuser, L

A population-based case-control study evaluated the relationship between soft tissue sarcoma and non-Hodgkin's lymphoma and past exposure to phenoxy herbicides and chlorophenols in western Washington state. A major purpose of the study was to determine if the risk of cancer was elevated in relation to chemicals potentially contaminated with 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD). A total of 160 men with soft tissue sarcoma and 581 men with non-Hodgkin's lymphoma were group-matched with 694 randomly selected controls and were interviewed in person. Among the general population, no increased risks for either cancer were seen in relation to intensity or duration of past exposure to phenoxy herbicides or chlorophenols. Preliminary risk estimates for specific occupations that involve phenoxy herbicide or chlorophenol exposure included: farmer, herbicide formulator, applicator, forest sprayer, farmland sprayer, work in sprayed area, and work with or manufacture chlorophenyls. In addition, the risks of both soft tissue sarcoma and non-Hodgkin's lymphoma were elevated among men with past exposure to various insecticides, organic solvents and metals, and among those with preexisting compromise of the immune system. Multivariate studies are in progress to ascertain the contribution of diverse factors to the risks of soft tissue sarcoma or non-Hodgkin's lymphoma in association with phenoxy herbicides, chlorophenols, and/or TCDD.

• Research Organization: Battelle Human Affairs Research Center, Seattle, WA
• OSTI ID: 6608883
• Report Number(s): CONF-860694-
• Journal Information: Am. J. Epidemiol.; (United States), Vol. 124:3; Conference: Conference of the Society for Epidemiologic Research, Pittsburgh, PA, USA, 11 Jun 1986
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HERBICIDES
BIOLOGICAL EFFECTS
HEALTH HAZARDS
PHENOLS
LYMPHOMAS
OCCUPATIONAL DISEASES
RISK ASSESSMENT
SARCOMAS
AROMATICS
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HAZARDS
HYDROXY COMPOUNDS
NEOPLASMS
ORGANIC COMPOUNDS
PESTICIDES
560300* - Chemicals Metabolism & Toxicology