Mutagenic activity and chemical analysis of airborne particulates collected in Pisa (Italy)

Journal Article · Tue Mar 01 00:00:00 EST 1994 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF00197838· OSTI ID:6607335

Vellosi, R; Fiorio, R; Rosellini, D; Bronzetti, G ^[1]; Vannucchi, C; Ciacchini, G; Giaconi, V ^[2]; Bianchi, F ^[3]

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1. Istituto di Mutagenesi e Differenziamento, Pisa (Italy)
2. Unita Operativa Chimica Ambientale, Pisa (Italy)
3. Istituto di Fisiologia Clinica, Pisa (Italy)

In the last few years there has been much concern about the problem connected to the exposure to mutagens present in the environment of industrialized countries. Particularly, the mutagenic activity of airborne particulate matter has been studied by many investigators and correlated with elevated lung cancer mortality rates. In most cases the Salmonella typhimurium/microsome test has been used for these studies. This short-term test, which is the most validated among the short-term genotoxicity tests, provides an important indication on the carcinogenic potential of environmental pollutants. That are complex mixtures containing a wide variety of compounds potentially capable of causing additive, antagonistic or synergistic genotoxic response in living organisms. Several studies have suggested that diverse factors, such as traffic and meteorological conditions, could affect the levels of pollutants in the air. In our work, we have investigated three different areas in Pisa, where the intensity and the kind of the road traffic were different. Airborne particles have been collected during a year and the genotoxic activity has been studied using TA98 and TA100 strains of Salmonella typhimurium. 20 refs., 1 fig., 3 tabs.

• OSTI ID: 6607335
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 52:3; ISSN 0007-4861
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ITALY
AIR POLLUTION
PARTICULATES
CHEMICAL ANALYSIS
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MUTATIONS
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