Gallium-67 scintigraphy in the evaluation of patients with clinical or laboratory evidence of hepatoma
Previous reports had shown that gallium-67 accumulates in hepatoma in 70 to 100% of cases according to different authors. The authors evaluated the significance of Ga-67 scintigraphy in 50 patients, 45 cirrhotics and 5 with other problems. All the patients had either focal defects (44) or patchy uptake (6) on a Tc-99m sulphur colloid scintigram (SC). Routine Ga-67 scintigraphy (5mCi, 48-72 hours imaging, planar gamma camera, medium energy collimator, 2-3 peak energy use) was performed and evaluated in conjunction with the associated Tc-99m SC scintigraphy. Of the 50 pts. 25 had hepatomas. All of them had focal defects on Tc-99m SC scans and incongruent gallium images with either filling of the defects or hot spots. Alfafetoprotein was measured in 18 patients and was normal in 5. Of the remaining 25 pts. without hepatoma 22 had cirrhosis (16 had focal defects and 6 patchy uptake on Tc-99m SC images, but all showed congruent gallium distribution, alfafetoprotein was measured in 12 pts. and was abnormally high in 5) and 3 had abscess, lymphoma or adrenal carcinoma (all had focal defect on Tc-99m SC images and incongruent gallium distribution with hot spots filling the defects of the Tc SC scan). In the series gallium was found to be very useful in separating focal liver abnormalities on Tc-99 SCS in cirrhotics. When a lesion didn't take up gallium, no hepatoma was present. When a defects on SC scintigraphy disappeared or picked up more activity on gallium, the patient had hepatoma (25), or abscess (1), lymphoma (1), adrenal ca. (1). In no case cirrhotic scarring showed gallium uptake. Alfafetoprotein, however, was positive in 5 cirrhotics and negative in 5 hepatomas.
- Research Organization:
- Univ. of Miami, Miami, FL
- OSTI ID:
- 6604635
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
Similar Records
Dual-tracer scintigraphy and subtraction studies in the diagnosis of hepatocellular carcinoma
Newly designed Tc(V)-99m dimercaptosuccinic acid: An agent of high accuracy for the diagnosis of head and neck and soft tissue tumors
Related Subjects
COLLOIDS
DIAGNOSTIC USES
LABELLING
GALLIUM 67
HEPATOMAS
DIAGNOSIS
SCINTISCANNING
LIVER
SULFUR COMPOUNDS
TECHNETIUM 99
BIOLOGICAL ACCUMULATION
BIOLOGICAL HOT SPOTS
COMPARATIVE EVALUATIONS
DEFECTS
DISTRIBUTION
GAMMA DETECTION
IMAGES
LABELLED COMPOUNDS
PATIENTS
PROTEINS
UPTAKE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DETECTION
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIATION DETECTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics